
✓ Dynamic and Accurate: CHI3L1 is the driving force of liver fibrogenesis, and dynamic assessment of progression/regression rate of liver fibrosis is better than the traditional static staging of fibrosis (stages 1-4).
✓ Specific and Sensitive: CHI3L1 has high liver specificity. At the cut-off value of 79ng/ml, the specificity and sensitivity of CHI3L1 for moderate and severe liver fibrosis are both over 90%, higher than other diagnostic methods.
✓ Non-invasive and Convenient: CHI3L1 is a stable serum biomarker whose level is not affected by ALT levels, ascites, serum bilirubin levels and other common factors. The diagnosis is non-invasive and is based on a single value from a single marker, which offers a safe and convenient method for fibrosis assessment.
A novel diagnostic marker with increased sensitivity for advanced liver fibrosis. Good discrimination for different stages of liver fibrosis using CHI3L1.
Supported by publications from top universities (e.g. Harvard University) in high-ranking journals
Used by Lab Corp.-one of the largest diagnostic laboratory service provider in the United States
CE mark approval
A novel diagnostic marker with increased sensitivity for advanced liver fibrosis (cirrhosis)
►Serum CHI3L1 levels were increased in alcoholic cirrhosis, post-hepatitic cirrhosis and non-cirrhotic fibrosis [6].
►Several studies have established that CHI3L1 is a biomarker for HCV-induced liver fibrosis and cirrhosis [6-9].
►CH13L1 was shown to be a biomarker for HBV-related liver fibrosis and cirrhosis [5].